Transient outward current carried by potassium and sodium in quiescent atrioventricular node cells of rabbits.
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چکیده
منابع مشابه
Transient outward current carried by potassium and sodium in quiescent atrioventricular node cells of rabbits.
Single atrioventricular node cells were dispersed by treating the rabbit heart with collagenase. In Tyrode's solution, the cells became rounded, and about 20% of them showed spontaneous activity, whereas the rest remained quiescent. When those quiescent cells were whole-cell clamped, depolarizing clamp pulses from the holding potential of -83 mV induced an outward current which decayed quickly,...
متن کاملSodium in Quiescent Atrioventricular Node Cells of Rabbits
Single atrioventricular node cells were dispersed by treating the rabbit heart with collagenase. In Tyrode's solution, the cells became rounded, and about 20% of them showed spontaneous activity, whereas the rest remained quiescent. When those quiescent cells were whole-cell clamped, depolarizing clamp pulses from the holding potential of —83 mV induced an outward current which decayed quickly,...
متن کاملTransient outward potassium current in ICC.
Interstitial cells of Cajal (ICC) are the pacemakers of the gut, initiating slow-wave activity. Several ion channels have been identified that contribute to the depolarization phase of the slow wave. Our aim was to contribute to knowledge about the identity and role of ICC potassium channels in pacemaking. Here we describe a transient outward potassium current in cell-attached patches of ICC. T...
متن کاملOutward sodium current in beating heart cells.
This article is a study of the fast Na current during action potentials. We have investigated the outward Na current (Mazzanti, M., and L.J. DeFelice. 1987. Biophys. J. 52:95-100) in more detail, and we have asked whether it goes through the same channels associated with the rapid depolarization phase of action potentials. We address the question by patch clamping single, spontaneously beating,...
متن کاملRole of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.
AIMS The transient outward potassium current (I(to)) plays important roles in action potential (AP) morphology and dynamics; however, its role in the genesis of early afterdepolarizations (EADs) is not well understood. We aimed to study the effects and mechanisms of I(to) on EAD genesis in cardiac cells using combined experimental and computational approaches. METHODS AND RESULTS We first car...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1985
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.57.1.65